Defenage Skincare

Skin Care

DefenAge is proven in 14 clinical trials to improve the visual appearance of aging skin. It also offers most of the advantages of time-honored retinol as well as newer but widely used growth-factor containing cosmeceuticals, without irritation or inflammation, sun-sensitivity, or concerns about neoplasia of the treated skin. Scientific research shows the defensin-molecule can reprogram dormant cells in our body to generate visibly newer, healthier, and youthful new skin.


This three-step full-size skincare system combines the latest in clinical anti-aging technology to address up to 16 signs of aging. DefenAge 8-in-1 BioSerum (1.0 oz) works with a proprietary blend of peptides, niacinamide, and potent botanicals to smooth wrinkles, brighten hyperpigmentation, and firm skin. 24/7 Barrier Balance Cream (1.5 oz) provides deep hydration while repairing the natural moisture barrier, and 2-Minute Reveal Masque (2.5 oz) gently exfoliates, refines pores, and clarifies with sugar crystals, papaya fruit enzymes, and lactic acid.



  • Skincare set targets 16 signs of aging with three full-size products
  • Peptides, niacinamide, and hyaluronic acid promote a youthful complexion
  • Dermatologist-tested and paraben-free
Skin Care


According to clinical studies, the reversion of skin aging to a youthful, healthy state is possible with the help of Age-Repair Defensins. It is available exclusively in DefenAge Skincare formulas. Defensins can reprogram your body to make skin visibly younger! Defensins are “target-specific” peptides, which means they only work with specific cells — in this case, LGR6+ stem cells. It “wakes up” LRG6+ stem cells, prompting them to make new basal stem cells. Although basal stem cells naturally create new cells, It becomes damaged over time. As a result, they create layers of cell damage every time they reproduce. DefenAge is the only skincare range that harnesses the power of Age-Repair Defensins to target specific stem cells and prompts them to produce new, fresh skin cells. The results: Several double-blind, placebo-controlled clinical studies have shown that DefenAge and its Age-Repair Defensins provide significant improvement in cosmetic skin elasticity and discoloration, skin evenness, the appearance of visible pores, fine lines and wrinkles, hydration levels, and excess oil.

Skin Care


The DefenAge range features five essential products that fit all skin types, skin tones, and ages. Recommended usage of the product can be daily, once or twice a week. It is an effective age-reversing regimen that harnesses the power of defensins. It significantly improves the appearance of these 15 top skin concerns:

  • Loss of firmness
  • Dark spots
  • Contour definition
  • Fine lines
  • Wrinkles Clogged, enlarged pores Sensitivity Uneven skin tone
  • Surface imperfections
  • Skin clarity
  • Loss of moisture
  • Dryness
  • Rough texture
  • Skin softness
  • Dullness

Defensin Regimen
24/7 Barrier Balance Cream

DefenAge’s patent-pending Age-Repair Defensin technology is a remarkably lightweight yet potent cream that hydrates brightens, refines, and energizes the skin. It visibly improves signs of aging. 24/7 Barrier Balance Cream comes in two varieties, with fragrance and with no fragrance added.


How to use?

Apply up to 2 pumps of cream onto fingertips. While skin is still moist, lightly massage your entire face and avoid the eye area. Use it twice daily after cleansing.

Skin Care

8-in-1 BioSerum

8-in-1 BioSerum Contains the highest concentration of Age-Repair Defensins. It is a “smart” serum that combines the skin-improving benefits of eight separate skincare treatments in one potent formula. The serum is also considered the cornerstone of the DefenAge regimen. It targets your skin’s unique needs and activates the repair process.


How to use?

Apply one pump on the face and another on the neck and décolleté 30 seconds after using the 24/7 Barrier Balance Cream. Begin application around the eyes before smoothing the serum over the entire face, neck, and décolletage.

Skin Care

2-Minute Reveal Masque

The 2-Minute Reveal Masque is effective in revealing smoother and brighter skin in minutes. It uses a blend of three enzymes and sugar crystals for gentle, effective exfoliation.

Using the product once or twice a week helps eliminate the buildup of dead and dull cells. The self-warming formula helps enhance the penetration of other DefenAge products. It is especially important for maximizing the defensins’ action.


How to use?

Apply to dry skin after cleansing. Using dry fingertips, gently massage the masque in a circular motion for 20 seconds or less (depending on skin sensitivity). Focus on the nose, forehead, chin, and other areas prone to blackheads and rough texture. Leave for two minutes before massaging with moist fingertips until the sugar crystals have dissolved, then rinse thoroughly.

Skin Care

1-Step Multi-Cleanse

This product formulates ingredients that stimulate the skin’s natural ability to enhance the defensins-response. The unique soap-free cleanser dissolves impurities within the pores and makeup (including waterproof mascara) in seconds. Featuring natural prebiotics, it is ideal for balancing the skin’s delicate ecology and preparing it for DefenAge products that follow.


How to use?

Massage a dime-sized amount onto dry skin for 15 seconds. Moisten fingertips and continue to massage in a circular motion until white cleansing milk develops. Rinse thoroughly with warm water.

Skin Care

3D Eye Radiance Cream

3D Eye Radiance Cream is a multi-tasking eye cream that targets all the main visible signs of aging. It helps lift, tighten, and smoothen the upper eyelids while improving the appearance of fine lines, crow’s feet, dark circles, and puffiness. It has an advanced application system that extends the performance of Age Repair Defensins. It is also fragrance-free and safe for contact lens wearers.


How to use?

After cleansing, while the skin is still moist from rinsing, pump a drop of cream onto the gold applicator tip. Lightly dab three dots of 3D Eye Radiance Cream above and below each eye. Use the applicator to massage cream around the eyes.

Skin Care

Before and After Gallery

Skin Care

Awards and Media

The Best Eye Cream for Dark Circles DefenAge® 3D Radiance Eye CreamNamed NewBeauty Award Winner

Skin Care

Eye Product of the Year

DefenAge 3D Eye Radiance Cream earned the accolade of the 2019 Beauty Independent Innovation Award.

Skin Care
Skin Care

Best Brightening Mask



NewBeauty Reveals DefenAge® 2-Minute Masque As Beauty Choice Awards Winner.

Skin Care

Non-surgical Innovator of the Year




DefenAge’s core regimen, the Clincal Power Trio, was honored by The Aesthetic Channel as the “Aesthetics Industry Award Winner”.




DefenAge Skincare was named Non-Surgical Innovator of the Year by The Aesthetic Channel powered by DermatologyTimes.

Skin Care
Skin Care

DefenAge Skincare sweeps 2020 Aesthetic Everything Awards with seven category wins!

  • Top Aesthetic Companies
  • Top Scar and Skin Repair Treatments
  • Top Medical Skincare Lines
  • Top Breakout Companies
  • Top SPA Skin Care lines
  • Top Aesthetic Publications
  • Top Aesthetic YouTube Videos
Skin Care


DefenAge “is the next biggest game-changer in topical products for anti-aging.”